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KMID : 0363320070280030510
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 3 p.510 ~ p.518
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Effect of Jaeumyangyung-tang on the Hyperglycemic Mice Induced with Streptozotocin
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Lee Hyung-Ho
Lee Young-Soo
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Abstract
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Objectives : The aim of this study was to investigate the effect of Jaeumyangyung-tang(滋陰養榮場(JY), JA-0.65g/kg;JB-1.3g/kg) on hyperglycemic mice induced with streptozotocin(STZ).
Methods : The experiment operated for 6 weeks. The rats were divided into 3 groups : diabetic group(control group), diabetic group treated with JA(0.65g/kg) for 6 weeks, and diabetic group treated with Jb(1.3g/kg) for 6 weeks.
Results : In the STZ-induced diabetic group, blood glucose levels significantly increased as well as the loss of body weight. The levels of serum glucose decreased significantly (p<0.05 or p<0.01) in the JA and JB groups compared with the control. According to a tolerance test, intraperitoneal glucose was ameliorated in the JA and JB groups. The blood urea nitrogen (BUN) and creatinine levels slightly decreased. Histologic analyses of the pancreases revealed that the {beta}-cells on Langerhans’ islets were destroyed by STZ, but the {beta}-cell mass was larger in the JY than in the control mice.
Conclusions : These results indicate that JY can exert beneficial effects on diabetes. preservation of in vivo {beta}-cell function and regeneration of {beta}-cell dysfunction by STZ.
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KEYWORD
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Jaeumyangyung-tang(滋陰養榮湯), Streptozotocin(STZ), Diabetes
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